Pyridine -2-suflonly aMide

Pyridine -2-suflonly aMide - Names and Identifiers

Name	pyridine-2-sulfonamide
Synonyms	2-pyridinesulfonamide pyridine-2-sulfonamide Pyridine -2-suflonly aMide pyridine-2-sulfonic acid amide 2-Pyridinesulfonamide(6CI,7CI,9CI)
CAS	63636-89-5
EINECS	201-525-2
InChI	InChI=1/C5H6N2O2S/c6-10(8,9)5-3-1-2-4-7-5/h1-4H,(H2,6,8,9)

Pyridine -2-suflonly aMide - Physico-chemical Properties

Molecular Formula	C5H6N2O2S
Molar Mass	158.18
Density	1.417±0.06 g/cm3(Predicted)
Melting Point	140-141 °C(Solv: ethanol (64-17-5); water (7732-18-5))
Boling Point	357.7±34.0 °C(Predicted)
Flash Point	170.138°C
Vapor Presure	0mmHg at 25°C
pKa	9.21±0.60(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.577

Pyridine -2-suflonly aMide - Introduction

pyridine-2-sulfonamide(pyridine-2-sulfonamide) is an organic compound with the chemical formula C5H6N2O2S.

Nature:
-Appearance: colorless or yellowish crystal
-Solubility: Soluble in water, alcohols and ketones, slightly soluble in ether solvents
-Density: approx. 1.41g/cm³
-melting point: about 170-175 ℃

Use:
-As a drug: pyridine-2-sulfonamide has antibacterial and anti-inflammatory activity, and is commonly used in the preparation of antibiotics, antibacterial agents and anti-inflammatory drugs.
-Can be used as a reagent in organic synthesis, such as in substitution reactions and condensation reactions.

Preparation Method:
pyridine-2-sulfonamide can be obtained by reacting pyridine with sulfuryl chloride. The specific preparation method can be:
1. pyridine is dissolved in hydrochloric acid, sulfur trioxide (SO3) is added, and the reaction generates pyridine-2-sulfonyl chloride.
2. Dissolve pyridine-2-sulfonyl chloride in an alkaline solution, add thionamide (NH2SO2) salts, and react with thionamide to generate pyridine-2-sulfonamide.

Safety Information:
- pyridine-2-sulfonamide is an organic compound with certain toxicity and should comply with safe operating procedures.
-contact with skin and eyes may cause irritation, should pay attention to protective measures.
-Inhalation or swallowing may cause poisoning. Maintain a well-ventilated working environment and avoid exposure to pyridine-2-sulfonamide airtight containers or solutions.
-In the case of accidental contact or ingestion, wash the affected area immediately and seek medical help.

Last Update：2024-04-09 15:17:59